Certified Registered Nurse Infusion (CRNI) Practice Exam

What infusion time is recommended for Vancomycin to prevent adverse reactions?

1. 30 minutes

2. 60 minutes

3. 90 minutes

4. 120 minutes

The correct answer is: 60 minutes

The recommended infusion time for Vancomycin is typically set at 60 minutes to prevent adverse reactions, particularly infusion-related reactions such as hypotension and "red man syndrome." Administering Vancomycin over a longer time frame, like 60 minutes, allows for a more gradual increase in plasma concentration, which can help to minimize the risk of these side effects. If Vancomycin is administered too quickly, it can trigger these serious reactions, prompting the need for slower administration rates in clinical settings. This is especially important in patients who may be at higher risk of complications, such as those with pre-existing conditions or those receiving other medications that might interact with Vancomycin. Choosing an infusion time shorter than 60 minutes may not allow enough time for the body to adjust to the medication, thereby increasing the chances of adverse reactions. On the other hand, longer infusion times do not necessarily enhance safety and may delay necessary treatment without providing additional protective benefits. Therefore, the 60-minute timeframe strikes an effective balance between efficacy and safety for the administration of Vancomycin.