Certified Registered Nurse Infusion (CRNI) Practice Exam

What is a common administration route for Amphotericin B?

1. Intramuscular

2. Intravenous

3. Subcutaneous

4. Oral

The correct answer is: Intravenous

Amphotericin B is a broad-spectrum antifungal drug primarily used to treat serious fungal infections. The most common route of administration for Amphotericin B is intravenous. This method allows for the drug to be delivered directly into the bloodstream, ensuring that it reaches therapeutic levels quickly and effectively in systemic infections. Intravenous administration is particularly important for Amphotericin B due to its pharmacokinetics; it tends to have poor oral bioavailability, meaning that if taken orally, much of the drug may not be absorbed effectively, leading to insufficient levels in the body to combat infections. While other routes such as intramuscular, subcutaneous, and oral may be used for various medications, they are not suitable for Amphotericin B, which requires the rapid and high-level delivery provided by intravenous administration to effectively treat severe fungal diseases.