Certified Registered Nurse Infusion (CRNI) Practice Exam

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Which medication binds only to fibrin?

Neupogen
Alteplase
Epogen
Lasix

The correct answer is: Alteplase

Alteplase is a tissue plasminogen activator (tPA) that is designed to dissolve blood clots. It works by binding specifically to fibrin, which is a protein involved in the clotting process. By targeting fibrin, alteplase promotes the conversion of plasminogen to plasmin, leading to the breakdown of fibrin and, hence, the dissolution of clots. This precise action makes alteplase effective in treating conditions like acute ischemic stroke, myocardial infarction, and massive pulmonary embolism, where rapid clot resolution is necessary. Its specificity for fibrin helps to minimize the risk of affecting other components of the hemostatic process, benefiting patient safety and treatment efficacy.