Certified Registered Nurse Infusion (CRNI) Practice Exam

Which of the following is a critical safety measure when administering Amphotericin B?

1. Use a one micron filter

2. Administer with a saline bolus

3. Monitor vital signs every 15 minutes

4. Give as a fast intravenous push

The correct answer is: Use a one micron filter

Using a one micron filter is a critical safety measure when administering Amphotericin B due to the risk of potential particulate matter and fungal contamination in the medication. Amphotericin B is a lipid-based antifungal agent, and its formulation can lead to the presence of aggregates or particles that could cause adverse reactions if introduced into the bloodstream. The one micron filter acts as a safety barrier that traps these particles, ensuring the medication delivered is safe and effective. This filtration step is particularly important given the serious nature of infections treated with Amphotericin B, such as systemic fungal infections, where any contaminants could pose significant risks to patient safety. Proper filtration helps in administering the drug without introducing harmful particles that could lead to complications. While other measures, like hydration or monitoring vital signs, are important in the context of administering Amphotericin B, the specific use of a one micron filter directly addresses the prevention of particulates entering the bloodstream.